IL-6 Negatively Regulates IL-22R<i>α</i> Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis

<div>IL-6R<i>α</i><sup>Δker</sup> mice present with increased epidermal hyperplasia following irritant exposure. Loss of the IL-6R<i>α</i> in keratinocytes promotes epidermal hyperplasia during irritant contact dermatitis. WT and IL-6R<i>α</i><sup>Δker</sup> mice were exposed to BKC or control for seven (7) consecutive days to induce ICD. 24 hours after irritant exposure, 8 mm biopsies of lesional skin were collected and embedded in O.C.T. compound for histological analysis. Skin samples were cross-sectioned and then hematoxylin and eosin (H&amp;E) stained. Representative H&amp;E stains from WT (a, b) and IL-6R<i>α</i><sup>Δker</sup> (c, d) are shown. Quantification of epidermal thickness (e) and cells per field (f) as determined by ImageJ (NIH) is presented. Data are <span class="nowrap"><svg height="9.10327pt" id="M1" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.75334 58.1969 9.10327" width="58.1969pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M797 0V26C739 32 732 36 732 103V296C732 394 682 449 605 449C576 449 550 437 529 423C504 407 475 389 446 366C425 418 382 449 334 449C303 449 279 437 253 421C222 403 201 385 180 371V452C135 432 85 419 41 411V388C99 379 102 374 102 310V103C102 38 93 32 27 26V0H238V26C189 32 180 38 180 103V338C210 363 250 390 289 390C351 390 377 348 377 275V103C377 37 368 32 306 26V0H520V26C465 32 456 38 456 101V296C456 314 455 326 453 338C491 369 529 390 565 390C628 390 653 345 653 274V107C653 36 642 32 583 26V0H797Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.595,0)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 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470 148 486 158Z"></path></g></svg>Significantly different from WT (<span class="nowrap"><svg height="11.7782pt" id="M3" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 44.5261 11.7782" width="44.5261pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M531 71V127L115 310L531 494V550L57 335V285L531 71ZM531 -40V10H57V-40H531Z"></path></g><g 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Journal of Immunology Research

fig1

Figure 1

Figure 1: IL-6 Negatively Regulates IL-22R<i>α</i> Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis 

Journal of Immunology Research

IL-6 Negatively Regulates IL-22Rα Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis

Figure 1