IL-6 Negatively Regulates IL-22R<i>α</i> Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis

<div>IL-6 negatively regulates IL-22R<i>α</i> expression on epidermal keratinocytes. Primary keratinocytes from IL-6KO mice were treated with rmIL-6 for 4/24 hours (mRNA/protein expression) at the indicated concentrations. The expression of IL-22R<i>α</i> mRNA was analyzed and normalized to 28S ribosomal RNA as control (a). IL-6KO keratinocytes were grown to confluency on multichamber slides. Immunohistochemical analysis of keratinocyte culture stained for the expression of IL-22R<i>α</i> (green), and nuclear staining DAPI (blue). Representative fluorescent images are shown at 20x (b–e) and 40x (f–i). Quantification of IL-22R<i>α</i> expression as determined by ImageJ (NIH) is presented (j and k). 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Journal of Immunology Research

fig3

Figure 3

Figure 3: IL-6 Negatively Regulates IL-22R<i>α</i> Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis 

Journal of Immunology Research

IL-6 Negatively Regulates IL-22Rα Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis

Figure 3