Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer

Figure 6

Measurement of the therapeutic efficiency of DC-CIK cells in tumor-bearing mice. ECA-109 cells were injected into nude mice to generate tumor-bearing mice. At 28 d, 29 d, 30 d, and 31 d after ECA-109 cell injection, DC-CIK cells were injected into the tumor-bearing mice. CIK cells were induced with DCs loaded with rPADI4. CIK cells induced with d-rPADI4-loaded DCs were used as control. (a) Tumor tissues were dissected from the tumor-bearing mice at 44 d after the ECA-109 cell injection. (b) MRI was used to measure the shape and size of the tumors at 44 d after the tumor cell injection. (c) Gross tumor volume was analyzed at 28 d, 32 d, 36 d, 40 d, and 44 d after the tumor cell injection based on Vernier caliper measurements.

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