TNFAIP3 Gene Polymorphisms in Three Common Autoimmune Diseases: Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Primary Sjogren Syndrome—Association with Disease Susceptibility and Clinical Phenotypes in Italian Patients

Table 1

Distribution of genotypes and alleles of the investigated TNFAIP3 polymorphisms in SLE, pSS, RA, and healthy controls.

		Genotypes					Alleles
rs2230926 T>G	N	TT	TG	GG	^a	OR	T	G		OR
CTRL	236	217	18	1			452	20
SLE	313	268	41	4	0.02	1.92 (1.09-3.38)	577	49	0.015	1.91 (1.12-3.28)
pSS	195	183	11	1	0.45	0.75 (0.35-1.58)	377	13	0.49	0.78 (0.38-1.59)
RA	256	229	26	1	0.23	1.45 (0.79-2.66)	484	28	0.37	1.31 (0.73-2.35)
rs6920220 G>A	N	GG	AG	AA	^a	OR	G	A		OR
CTRL	228	176	45	7			397	59
SLE	308	212	91	5	0.03	1.53 (1.03-2.27)	515	101	0.12	1.32 (0.93-1.87)
pSS	195	130	56	9	0.016	1.69 (1.1-2.6)	316	74	0.02	1.55 (1.07-2.26)
RA	256	151	93	12	<0.0001	2.35 (1.58-3.50)	395	117	<0.0001	1.99 (1.42-2.81)

^aHeterozygous and homozygous variant genotypes were considered together (one degree of freedom) in the comparisons. CTRL: healthy controls; SLE: systemic lupus erythematosus; pSS: primary Sjogren’s syndrome; RA: rheumatoid arthritis; OR: odds ratio. Significant associations are reported in bold.