Sm16, A Schistosoma mansoni Immunomodulatory Protein, Fails to Elicit a Protective Immune Response and Does Not Have an Essential Role in Parasite Survival in the Definitive Host

Table 3

Reduction in the parasite burden from mice infected with Sm16-silenced schistosomula.

	Worm burden recovery ()	% reduction	Eggs/gram of liver ()	% reduction^#	Eggs/gram of intestine ()	% reduction^#
Trial 1
Control
GFP	30 +/-14	NS		NS		NS
Sm16		8% (NS)		8.6% (NS)		NS
Trial 2
Control
GFP		5.3% (NS)		0.5% (NS)		30% (NS)
Sm16		NS		NS		NS

Reduction of total worms compared to control group. ^#Reduction of eggs in tissue (liver and intestine) compared to the control group. NS: not significant.