Induction of Macrophage M2b/c Polarization by Adipose Tissue-Derived Mesenchymal Stem Cells

Figure 8

The relative expression of a series of pathway proteins in different groups of macrophages. After ADMSC induction, nonactivated Mφ and LPS-induced M1-Mφ increased their expression of p-STAT6 and its downstream IRF4 (d and e). On the contrary, IL-4/13-induced M2-Mφ decreased their expression after ADMSC induction. On the other hand, after ADMSC induction, LPS-induced M1-Mφ and IL-4/13-induced M2-Mφ increased their expression of p-STAT3 and its downstream SOCS3 (b and c). The expression of p-STAT3 in nonactivated Mφ showed no significant change after ADMSC induction, while the expression of SOCS3 decreased.

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