Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population

<div>Antibody-dependent enhancement of ZIKV by DF and DHF sera. Serially diluted sera were mixed and incubated for 1 h with <svg height="11.786pt" id="M19" style="vertical-align:-0.3499002pt" version="1.1" viewbox="-0.0498162 -11.4361 78.7719 11.786" width="78.7719pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.24,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.204,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z"></path></g><g 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Infection was analyzed by flow cytometry. (a) Representative dot plots of the ADE of one DF serum sample (A) and one DHF serum sample (B). (b) Enhancement of ZIKV by DF (A) and DHF (B) serum samples represented as percent of infection. (c) Comparison of both groups DF and DHF; each serum sample was graphed at the maximum dilution where at least 5% ADE was still observed. As a positive control, 4G2 serum was used for ADE. 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Journal of Immunology Research

fig5

Figure 5

Figure 5: Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population 