Research Article

Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population

Figure 5

Antibody-dependent enhancement of ZIKV by DF and DHF sera. Serially diluted sera were mixed and incubated for 1 h with of ZIKV and used to infect K562 cells for 24 h. Infection was analyzed by flow cytometry. (a) Representative dot plots of the ADE of one DF serum sample (A) and one DHF serum sample (B). (b) Enhancement of ZIKV by DF (A) and DHF (B) serum samples represented as percent of infection. (c) Comparison of both groups DF and DHF; each serum sample was graphed at the maximum dilution where at least 5% ADE was still observed. As a positive control, 4G2 serum was used for ADE. Bars represent the . , , and .