Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice

Figure 2

Budesonide attenuated lung edema. C57BL/6 mice were administered with LPS (5 mg/kg, i.t.) with/without budesonide pretreatment (0.5 mg/kg). Twelve hours after the LPS injection, the BALF was collected, and total protein concentrations were detected with a BCA kit (a). Lungs were collected for W/D ratio detection (b). Data were expressed as deviations (). compared with the control group and compared with the ALI group.

(a)

(b)