Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta
LCMV replication is more robust in the first-trimester placental explants. (a) The first-trimester human placental explants are permissive to viral replication at multiple gestational ages (/group). (b) LCMV titer placental villus explant tissue lysates from the first trimester and term. (c) LCMV viral secretion into the media starting at day 4 after infection. (d) LDH release by the first-trimester and term placentas. Data is presented as the mean and standard deviation of four different subjects in each group. Significance () was determined by ANOVA.