Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta
Cytokine secretion is seen in response to LCMV in term placental explants but not in the first-trimester tissue. Term and the first-trimester placental explants were analyzed for cytokine secretion after infection. (a) TNF-α, (b) IL-6, and (c) IFN-γ. Mean and standard deviation are shown. Significance is defined as a value ≤ 0.05 comparing the first vs. third trimester, denoted by ( per group).