A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction

Figure 1

The complex mechanisms underlying HBP release. (a) Prosecretion factors stimulate PMNs to release HBP following an influx of Ca²⁺. (b) The specific signaling pathways of different factors responsible for activating PMNs, including PSMα4/LTB4/suilysin-receptor-PI3K, suilysin-GPCR-P38, fibrinogen-M1-β integrin, streptolysin O-P38/Ca²⁺ influx, and endothelin-ET receptor.

(a)

(b)