An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders

Table 1

Protein shape and arginine position effect on citrullination efficiency.

Arginine position	Kinetic of citrullination	Protein shape	Kinetics of citrullination
N-Arg-Glu-C	Hardly citrullinated	α-Helix	Difficult to be citrullinated
N-Arg-Asp-C	Highly and efficiently citrullination (100%)	β-Turn	The most liable form for citrullination
N-Arg-Arg-C	Arg near C-terminus excluding MBP case	Disordered	Easily and efficiently citrullinated (95%)
N-Pro-Arg-Pro-C	Never citrullinated	β-Sheet	No data available
Arg close to N-terminus	Difficult to be citrullinated