Infiltration of Blood-Derived Macrophages Contributes to the Development of Diabetic Neuropathy

Figure 1

Development of hyperglycemia and mechanical allodynia in diabetic mice. (a) Blood glucose of diabetic mice increased significantly at each time point 1 week after STZ injection. (b) Diabetic mice did not gain weight, in contrast to their nondiabetic counterparts. (c) The mechanical withdrawal threshold of diabetic mice started decreasing significantly 2 weeks after STZ injection and persisted throughout the study period (, , and vs. nondiabetic mice at all time points; 2-way RM-ANOVA and LSD posttest). mice per group.

(a)

(b)

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