Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice
Constitutive TL1A expression on myeloid cells aggravated liver injury, hepatocyte necrosis, and apoptosis. (a, b) H&E staining showed that the hepatocyte necrosis area in the CCl4/Tg group was significantly larger than that in the CCl4/WT group (200x). (c, d) The apoptotic hepatocytes were significantly increased in the CCl4/WT group than in the Control/WT group and Oil/WT group, and more apoptotic hepatocytes were found in the CCl4/Tg group, compared with the CCl4/WT group (200x). (e) Serum ALT, AST, and TBIL in the CCl4/Tg group were significantly higher than those in the CCl4/WT group. Data are expressed as mean ± SD, and .