Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice

Figure 2

Constitutive TL1A expression on myeloid cells aggravated liver injury, hepatocyte necrosis, and apoptosis. (a, b) H&E staining showed that the hepatocyte necrosis area in the CCl₄/Tg group was significantly larger than that in the CCl₄/WT group (200x). (c, d) The apoptotic hepatocytes were significantly increased in the CCl₄/WT group than in the Control/WT group and Oil/WT group, and more apoptotic hepatocytes were found in the CCl₄/Tg group, compared with the CCl₄/WT group (200x). (e) Serum ALT, AST, and TBIL in the CCl₄/Tg group were significantly higher than those in the CCl₄/WT group. Data are expressed as mean ± SD, and .

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