Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice

<div>Constitutive TL1A expression on myeloid cells exacerbated liver fibrosis. (a) The Sirius Red-positive area in the CCl<sub>4</sub>/Tg group was markedly larger than that in the CCl<sub>4</sub>/WT group (200x). (b) The hydroxyproline content in the CCl<sub>4</sub>/Tg group was higher than that in the CCl<sub>4</sub>/WT group. (c–e) The Collagen1<i>α</i>1 expressions in the CCl<sub>4</sub>/Tg group were remarkably higher than those in the CCl<sub>4</sub>/WT group detected by RT-PCR, immunohistochemical staining (200x), and Western blot. 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Journal of Immunology Research

fig3

Figure 3

Figure 3: Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice 