Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice
Constitutive TL1A expression on myeloid cells exacerbated liver fibrosis. (a) The Sirius Red-positive area in the CCl4/Tg group was markedly larger than that in the CCl4/WT group (200x). (b) The hydroxyproline content in the CCl4/Tg group was higher than that in the CCl4/WT group. (c–e) The Collagen1α1 expressions in the CCl4/Tg group were remarkably higher than those in the CCl4/WT group detected by RT-PCR, immunohistochemical staining (200x), and Western blot. Data are expressed as mean ± SD, and .