Research Article
STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren’s Syndrome: Association with Disease Susceptibility and Clinical Aspects
Table 2
Case-control association study.
| STAT4 rs7574865 | SS () | Controls () | | OR (95% CI) | Genotypes | GG | 92 | 150 | 0.002 | 1.81 (1.23-2.65) | GT | 78 | 87 | TT | 25 | 6 | Alleles | G | 262 | 387 | 0.00003 | 1.91 (1.41-2.59) | T | 128 | 99 |
| HCP5 rs3099844 | SS () | Controls () | | OR (95% CI) | Genotypes | CC | 149 | 221 | 0.0003 | 2.53 (1.5-4.24) | CA | 44 | 27 | AA | 2 | 0 | Alleles | C | 342 | 469 | 0.0003 | 2.44 (1.49-3.99) | A | 48 | 27 |
| TRAF3IP2 rs33980500 | SS () | Controls () | | OR (95% CI) | Genotypes | CC | 167 | 183 | 0.63 | 0.88 (0.51-1.5) | CT | 28 | 34 | TT | 0 | 1 | Alleles | C | 362 | 400 | 0.57 | 0.86 (0.51-1.44) | T | 28 | 36 |
| IL10 rs1800872 | SS () | Controls () | | OR (95% CI) | Genotypes | CC | 117 | 130 | 0.004 | 0.58 (0.40.0.84) | CA | 66 | 124 | AA | 11 | 24 | Alleles | C | 300 | 384 | 0.005 | 0.65 (0.49-0.88) | A | 88 | 172 |
| IL10 rs3024505 | SS () | Controls () | | OR (95% CI) | Genotypes | CC | 137 | 209 | 0.1 | 1.43 (0.94-2.17) | CT | 48 | 58 | TT | 9 | 3 | Alleles | C | 322 | 476 | 0.025 | 1.52 (1.05-2.21) | T | 66 | 64 |
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GT vs. GG: and ; TT vs. GG: and ; value evaluated by Pearson’s test; OR (95% CI) = odd ratios with 95% confidence interval. |