Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye
Table 2
Demographic and clinical characteristics of patients according to autoimmune disease status.
Primary SS ()
Secondary SS ()
Other autoimmune disease ()
No known autoimmune disease ()
value
Demographics
Age (years), mean (SD)
58 (8.4)
61 (15.5)
58 (15.3)
60 (10.9)
0.82
Female, n (%)
11 (100%)
7 (100%)
18 (86%)
79 (81%)
0.26
SS-related symptoms, n (%)
Dry mouth
3 (27%)
2 (29%)
8 (38%)
30 (31%)
0.91
Joint/muscle pain
2 (18%)
0
2 (9%)
20 (21%)
0.38
Fatigue
2 (18%)
1 (14%)
1 (5%)
13 (13%)
0.67
Diagnostic parameters, n (%)
Anti-SSA
9 (82%)
4 (57%)
0
0
Anti-SSB
3 (27%)
2 (29%)
0
0
RF
5 (46%)
4 (57%)
3 (14%)
2 (2%)
6 (55%)
3 (42%)
3 (14%)
2 (2%)
Positive biopsy
2/3 (67%)
0/1 (0%)
0/2 (0%)
0/7 (0%)
Novel autoantibodies, n (%)
8 (73%)
1 (14%)
10 (48%)
37 (38%)
0.06
Anti-SP1
3 (27%)
1 (14%)
2 (9%)
13 (13%)
0.57
Anti-CA6
3 (27%)
0
5 (24%)
21 (22%)
0.53
Anti-PSP
6 (54%)
0
4 (19%)
10 (10%)
0.001
Dry eye measures, mean (SD)
Tear osmolarity (mOsm/L)
323 (33.7)
308 (17.4)
307 (17.7)
307 (14.5)
0.054
Schirmer test (mm)
9.0 (8.1)
4.8 (3.6)
7.7 (11.5)
7.9 (6.7)
0.79
Schirmer mm, n (%)
5 (71%)
2 (67%)
7 (78%)
25 (43%)
0.14
Total OSS (0-12)
8.3 (3.3)
8.6 (1.8)
7.2 (2.7)
5.5 (3.5)
0.003
Corneal staining (0-6)
3.3 (1.8)
3.4 (1.5)
2.9 (1.9)
2.3 (1.8)
0.15
Conjunctival staining (0-6)
5.0 (1.8)
5.1 (1.2)
4.4 (1.6)
3.2 (2.3)
0.002
,n (%)
6 (60%)
4 (67%)
13 (68%)
60 (72%)
0.97
mm or ,n (%)
8 (73%)
5 (83%)
17 (85%)
70 (75%)
0.77
Results are represented as mean (standard deviation) for continuous variables and number (percentage) for binary variables. The one-way analysis of variance (ANOVA) was used for comparison of continuous variables and chi-squared testing for categorical variables between groups. SS: Sjögren’s syndrome; SD: standard deviation; SSA: Sjögren’s syndrome-related antigen A; SSB: Sjögren’s syndrome-related antigen B; RF: rheumatoid factor; ANA: antinuclear antibody; SP1: salivary protein 1; CA6: carbonic anhydrase 6; PSP: parotid secretory antigen; OSS: ocular staining score.
