Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency

Figure 1

The mechanisms of inflamm-aging. In the process of aging, with the activation of inflammatory factors, the body appears to be in a chronic, progressively elevated proinflammatory state called inflammatory aging. ROS in the body is increased due to several factors. It causes oxidative stress and a series of inflammatory reactions activated by NLPR3 and NF-κB. It is now summarized as follows: oxidative stress inflammation, cytokines, DNA damage, autophagy, and nonenzymatic glycation.