Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases

Figure 2

Zinc in intestinal epithelial cells ZIP14 and GPR39 mediates the establishment of the physical barrier through tight junctions (a). ZIP7 and ZIP4 contribute to the maintenance of intestinal homeostasis by securing continuous epithelial turnover (b). ZnT2 facilitates zinc accumulation into the secretory granule, contributing to the antimicrobial function of Paneth cells.

(a)

(b)

(c)