Bone Marrow Mesenchymal Stem Cells Decrease the Expression of RANKL in Collagen-Induced Arthritis Rats via Reducing the Levels of IL-22

Figure 1

Therapeutic effects of MSCs in CIA rats. A decrease in severity of CIA following MSC transplantation is shown by X-ray (a, b, c) and HE stains (d, e, f). After injecting MSCs to CIA rats for 30 days, the X-ray showed that the joints of CIA rats (b, e) had osteoporosis and destruction compared with normal controls (a, d), and MSC transplantation reduced the damage of the joint with a wider joint space (c, f). MSCs: bone marrow mesenchymal stem cells; CIA: collagen-induced arthritis.

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