Bone Marrow Mesenchymal Stem Cells Decrease the Expression of RANKL in Collagen-Induced Arthritis Rats via Reducing the Levels of IL-22

Figure 4

Density of IL-22 and RANKL in FLSs by immunohistochemistry. The levels of IL-22 and RANKL in the three groups were significantly different (IL-22: , ; RANKL: , ). The mean densities of IL-22 and RANKL in the CIA controls ( and , respectively) were higher than those in the normal controls ( and , respectively). After treating with MSCs, the mean densities of IL-22 and RANKL in FLSs were reduced (CIA-MSC group: and , respectively). IL-22: interleukin-22; RANKL: receptor activator of nuclear factor-kappa B ligand; FLSs: fibroblast-like synoviocytes. Significant between-group difference (). Significant between-group difference (). Significant between-group difference ().

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