Bone Marrow Mesenchymal Stem Cells Decrease the Expression of RANKL in Collagen-Induced Arthritis Rats via Reducing the Levels of IL-22

Figure 6

The expression of RANKL mRNA in FLSs treated with different doses of IL-22: (a) 0 ng/ml IL-22; (b) 0.1 ng/ml IL-22; (c) 1 ng/ml IL-22; (d) 5 ng/ml IL-22. The expression of RANKL mRNA in CIA controls was the highest among the three groups. The difference was statistically significant (0 ng/ml: , ; 0.1 ng/ml: , ; and 5 ng/ml: , ), expect for adding 1 ng/ml IL-22 to the three groups (, ). IL-22: interleukin-22; RANKL: receptor activator of nuclear factor-kappa B ligand; FLSs: fibroblast-like synoviocytes. Significant between-group difference (). Significant between-group difference (). Significant between-group difference ().

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