DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma

<div>DKK2 was highly expressed in PDAC and was associated with poor prognosis in PDAC patients. (a, b) The mRNA expression level between tumor tissue and adjacent normal tissue in GSE15471 dataset, TCGA data, Oncomine, GTEx data, and Renji cohort. (c) DKK2 expression plot of various types of cancer from TCGA database. (d) Representative scoring criterion images of immunohistochemical staining of DKK2 expression in 208 paired PADC tumor and adjacent nontumor tissues. Scale bar: 50 <i>μ</i>m. (e) DKK2 was upregulated in PDAC tumor tissues. (f) High DKK2 expression correlated with inferior survival time. Abbreviations: TCGA: The Cancer Genome Atlas; GTEx: Genotype-Tissue Expression. 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Journal of Immunology Research

fig1

Figure 1

Figure 1: DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma 