DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma

Table 2

Univariate and multivariate analyses of prognostic parameters for survival in PDAC patients.

Prognostic parameter	Univariate analysis			Multivariate analysis
	RR	95% CI	value	RR	95% CI	value
DKK2 (low vs. high)	1.729	1.24-2.412	0.001	1.789	1.27-2.52	0.001
Age (<60 vs. ≥60)	0.765	0.552-1.058	0.105
Gender (male vs. female)	0.989	0.87-1.125	0.865
Tumor location (head vs. body/tail)	0.999	0.713-1.399	0.996
Size (≤2 cm vs. >2 cm)	1.729	1.030-2.902	0.038	1.606	0.923-2.794	0.094
Tumor differentiation (well vs. moderate/poor)	2.125	0.938-4.813	0.071
T classification (T1 vs. T2 vs. T3 vs. T4)	0.834	0.503-1.383	0.482
AJCC stage (I vs. II vs. III vs. IV)	1.374	1.072-1.76	0.012	0.927	0.678-1.266	0.633
N classification (absent vs. present)	0.788	0.317-1.959	0.608
Liver metastasis (absent vs. present)	4.937	2.536-9.61	<0.001	6.569	2.656-16.245	<0.001
Vascular invasion (absent vs. present)	0.327	0.044-2.419	0.273

Bold value with asterisk means it has significant difference. RR: relative risk; CI: confidence interval; .