Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis

<div>MRP14 protects multiple myeloma cells from apoptosis. (a) Expression of BAFF mRNA in immune cells. Data from BioGPS are presented as raw expression values. Myeloma plasma cells were cultured with doxorubicin for 24 hours (b) with neutrophils or (c) with BAFF plus MRP14. Annexin V-positive cells were shown for the apoptotic plasma cells. (d) Coculture with neutrophils or MRP14 enhanced the surface level of the BAFF receptor of myeloma cells, which is determined using flow cytometry. 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Journal of Immunology Research

fig5

Figure 5

Figure 5: Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis 