Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity
Table 2
TCRζ gene polymorphisms in 44 gastric cancer patients and 33 control subjects.
Genotype
WT/WT
WT/POL
POL/POL
SNP
Controls
Patients
Controls
Patients
Controls
Patients
()
(%)
()
(%)
()
(%)
()
(%)
()
(%)
()
(%)
373 C/T
7
87.5
12
85.7
1
12.5
2
14.3
0
0.0
0
0.0
856 G/A
7
87.5
14
100.0
1
12.5
0
0.0
0
0.0
0
0.0
1235 C/G
8
100.0
14
100.0
0
0.0
0
0.0
0
0.0
0
0.0
1343 ins/G
6
75.0
11
78.6
2
25.0
2
14.3
0
0.0
1
7.1
1453 C/G
6
75.0
11
78.6
2
25.0
2
14.3
0
0.0
1
7.1
1460 T/A
6
75.0
9
64.3
2
25.0
3
21.4
0
0.0
2
14.3
1542 G/A
6
100.0
10
83.3
0
0.0
1
8.3
0
0.0
1
8.3
1553 A/T
6
100.0
12
100.0
0
0.0
0
0
0
0.0
0
0.0
1572 G/A
2
40.0
1
8.3
3
60.0
11
91.7
0
0.0
0
0.0
WT: wild type; POL: polymorphism; : sample size SNP; new polymorphisms deposited at the GenBank with the accession numbers EF364119, EF364117, and EF364118, respectively.
