Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix

Figure 1

Haematoxylin and eosin (HE) staining as well as immune checkpoint protein expression in samples of clear cell carcinoma (a–f) and squamous cell carcinoma (g–l) of the uterine cervix: (a) HE, (b) positive programmed cell death-ligand 1 (PD-L1) expression in tumour cells (TCs) and tumour-associated immune cells (TAICs), (c) positive B7-H3 expression in TCs, (d) positive B7-H4 expression in TCs, (e) positive V-domain Ig suppressor of T cell activation (VISTA) expression in TAICs, (f) negative VISTA expression in TCs, (g) HE, (h) positive PD-L1 expression in TCs and TAICs, (i) positive B7-H3 expression in TCs, (j) positive B7-H4 expression in TCs, (k) positive VISTA expression in TAICs, and (l) positive VISTA in TCs. All the images are at ×200 magnification.

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