Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders

Table 2

Studies that have used molecular tools to explore the role of specific HDACs in B cell biology and behavior. The table summarizes published papers that have used molecular approaches and/or knockout models to better understand the relevance of a particular HDAC in the context of B cell behavior and biology.

	Target	Effect	Cell line	Model	Reference
HDAC 1	Myc	Suppresses tumor growth in Eμ-myc-driven B cell lymphoma	HDAC 1 knockout mice	Mouse	[89]
	p21 upregulation	Cell growth inhibition and apoptosis induction	shRNA RS4;11; SEMK2 cells	Human	[75]
	No defined molecular target	Increased cell death	shRNA RS4;11, REH, 697, and SEMK2 cells
HDAC 2	Myc	Suppresses tumor growth in Eμ-myc-driven B cell lymphoma	HDAC 1 knockout mice	Mouse	[89]
	p21 upregulation	Cell growth inhibition and apoptosis induction	shRNA RS4;11; SEMK2 cells	Human	[75]
	No defined molecular target	Increased cell death	shRNA RS4;11, REH, 697, and SEMK2 cells
HDAC 3	MHC class II gene expression	Blocks lymphoma growth	Lymphoma cell lines (OCI-Ly7, MD901, OCI-Ly18, OZ, and RIVA)	Human	[90]
	p21 and H2AX increased levels	Increased cell death	shRNA RS4;11, REH, 697, and SEMK2 cells	Human	[75]
HDAC 4	miR-155	Upregulation decreases proliferation and clonogenic potential and increases apoptosis	Eμ-miR-155 transgenic mouse model	Mouse	[91]
HDAC 6	No defined molecular target	HDAC 6 is upregulated	MRL/lpr mouse autoimmunity; Bone marrow and splenic B cells	Mouse	[68]
	Activation of ECM signaling	Differentially expressed in human diffuse large B cell lymphoma tissues; correlated with poor prognosis	Patient sample; NuDUL-1	Human	[92]
HDAC 7	Itgam and CD69 promoter	Pro-B to pre-B cell transition blockade; severe lymphopenia in peripheral organs	Pro-B cells	Mouse	[93]
HDAC 9	No defined molecular target	HDAC 9 is upregulated	MRL/lpr mouse autoimmunity; Bone marrow B cells	Mouse	[68]
	BCL6; p53	Constitutive expression induces lymphomagenesis	Eμ-HDAC 9 transgenic mouse	Mouse	[94]
HDAC 10	No defined molecular target	HDAC 10 is downregulated	MRL/lpr mouse autoimmunity; Bone marrow B cells	Mouse	[68]
		HDAC 10 is upregulated	MRL/lpr mouse autoimmunity; Splenic B cells	Mouse	[68]
HDAC 11	IL-10	Allergy (rhinitis)	Patients	Human	[95]