The Effectiveness of Rapamycin Combined with Eltrombopag in Murine Models of Immune-Mediated Bone Marrow Failure

Figure 4

Efficacy of rapamycin combined with eltrombopag on NK functional molecules. The expression of NKG2A was significantly downregulated and NKG2D upregulated in the AA group compared with the NC group (). The expression of NKG2A on peripheral regulatory and functional NK cells was upregulated in the CsA group, Rapa group, and Rapa+Elt group (). The expression of NKG2D on the peripheral regulatory and functional NK cells was downregulated in the CsA, Rapa, and Rapa+Elt groups compared with the AA group, but there is statistical significance only for functional NK cells (). Moreover, there is no notable difference in the NKG2A and NKG2D expression between the Rapa group and Rapa+Elt group. There was no significant difference between the effect of Rapa and CsA on the function of NK cells.