The Effectiveness of Rapamycin Combined with Eltrombopag in Murine Models of Immune-Mediated Bone Marrow Failure

Figure 6

Efficacy of rapamycin combined with eltrombopag on T lymphocytes subsets. (a) Column diagram of the efficacy of rapamycin combined with eltrombopag on CD4+/CD8+T ratio and the secretion IFN-γ in CD8+T cells. Compared with the NC group, the AA group showed a decreased CD4+/CD8+ ratio (). The results showed that the CD4+/CD8+ ratio in the CsA group, Rapa group, and Rapa + Elt group had an obvious elevation than the AA group (all ). There was no significant difference among the effect of Rapa, CsA, and Rapa+Elt on the CD4+/CD8+ ratio. As for IFN-γ, Rapa can reduce the secretion of IFN-γ from CD8+T cells with efficacy similar to that of the standard dose of CsA and had a better outcome when combined with Elt in bone marrow failure mice. (b) Representative flow cytometry analyses of CD4+/CD8+T ratio. (c) Representative flow cytometry analyses of the secretion IFN-γ in CD8+T cells.

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