After Treatment Decrease of Bone Marrow Tregs and Outcome in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia

Table 3

Factors affecting overall response.

	Response, patients
	Yes	No.
	(54%)	(46%)	p
Age
Years, median value	52	56	ns^a
Range	(19-65)	(35-65)
WBC
WBC/μl, median value	4750	21290	ns^a
Range	(1400-146000)	(1900-281000)
Molecular/cytogenetic group^@, %			0.02^b; 0.03^d
Poor	2 (10)	8 (44)
Intermediate	16 (76)	10 (56)
Good	3 (14)	0 (0)
NPM/FLT3 , %
NPM1^mut	8 (38)	0 (0)	0.004^c; 0.05^d
NPM1^wt	13 (62)	18 (100)
FLT3 ITD+ or D835+	5 (24)	4 (22)	ns^c
FLT3^wt	16 (76)	14 (78)
NPM1^mut/FLT3^wt/NK	3 (14)	0 (0)	ns^c
No (NPM^mut/FLT3^wt/Nk)	18 (86)	18 (100)
dBMA Tregs			ns^a
Median value	21	12
Range	(2-78)	(2-82)
De novo AML , %			ns^c
Yes	20 (95)	13 (72)
No	1 (5)	5 (28)

^@according to ELN 2010 [ITD allelic ratio not performed]. WBC: white blood cells; dBMA Tregs: diagnostic bone marrow aspirate T regulatory cells; NK: normal karyotype; AML: acute myeloid leukemia. ^aMann–Whitney rank sum test, ^bchi-square test, ^cFisher’s exact test, ^dMultivariate stepwise-backward elimination procedure; Bold values are statistically significant ().