Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin-Resistant HepG2 Cells through the PPM1B Pathway

Figure 9

Effect of BBR on the PI3K/AKT pathway in HepG2-IR cells. (a) Representative Western blotting results of PI3K p85, pAKT Ser473, AKT, pIRS-1 Ser307, IRS-1, pIRS-2 Ser731, IRS-2, and nucleoprotein NF-κB p65. (b–i) Semiquantitative analysis of PI3K p85, pAKT Ser473, AKT, pIRS-1 Ser307, IRS-1, pIRS-2 Ser731, IRS-2, and nucleoprotein NF-κB p65. The experiments were repeated three times and presented as . ^▲ and ^▲▲, Con vs. model; and , model vs. BBR-treated groups.

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