miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes
Table 3
ROC curve analysis for microRNA-125a and microRNA-451a to diagnose structural damage in AS patients.
AUC
Cutoff
Sensitivity (%)
Specificity
PPV
NPV
Accuracy
To distinguish AS patients from controls
MicroRNA-125a
0.788
<0.001
3.029
70.91
83.64
81.2
74.2
77.3
MicroRNA-451a
0.802
<0.001
3.372
65.45
78.18
75.0
69.4
71.8
To diagnose active AS patients from inactive patients
MicroRNA-125a
0.777
<0.001
5.815
62.07
80.77
78.3
65.6
70.9
MicroRNA-451a
0.782
<0.001
2.979
68.97
76.92
76.9
69.0
72.7
To detect structural damage in AS patients
MicroRNA-125a
0.775
0.001
5.637
65.62
78.26
80.8
62.1
70.9
MicroRNA-451a
0.692
0.016
2.979
62.50
73.91
76.9
58.6
67.3
AUC: area under a curve; value: probability value; CI: confidence intervals; NPV: negative predictive value; PPV: positive predictive value. Statistically significant at .
