Journal of Immunology Research / 2020 / Article / Tab 1 / Review Article
Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy Table 1 TCR-like antibody CAR-T cell therapy in human diseases.
Antigen Epitope sequence MHC allele Clone Generation strategy CAR sequence Human disease Reference MAGE-1 EADPTGHSY HLA-A Fab-G8 Phage Fab-G8-CD4/γ Melanoma [18 ] EADPTGHSY HLA-A Fab-G8/Fab-Hyb3 Phage Fab-G8/γ γ Melanoma [22 ] Proteinase 3 VLQELNVTV HLA-A 8F4 Hybridoma 8F4-28Z AML [24 ] WT1 RMFPNAPYL HLA-A F2, F3 Phage F2-28Z/F3-28Z Leukemia [26 ] RMFPNAPYL HLA-A Clone 45 Phage Clone45-4-1BBZ Leukemia [23 ] HA-1H VLHHDLLEA HLA-A #131 Phage #131-28Z Leukemia [19 ] NY-ESO-1 SLIMWITQC HLA-A T1 Phage T1-28Z Melanoma [25 ] AFP FMNKFIYET HLA-A ET1402L1 Phage ET1402L1-28Z Liver cancer [27 ]
Notes: published TCR-like antibody CAR-T targeting cancer antigens are summarized. MHC: major histocompatibility complex; CAR: chimeric antigen receptor.
