Journal of Immunology Research / 2020 / Article / Tab 1

Review Article

Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy

Table 1

TCR-like antibody CAR-T cell therapy in human diseases.

AntigenEpitope sequenceMHC alleleCloneGeneration strategyCAR sequenceHuman diseaseReference

MAGE-1EADPTGHSYHLA-A0101Fab-G8PhageFab-G8-CD4/γMelanoma[18]
EADPTGHSYHLA-A0101Fab-G8/Fab-Hyb3PhageFab-G8/γ
Fab-Hyb3/γ
Melanoma[22]
Proteinase 3VLQELNVTVHLA-A02018F4Hybridoma8F4-28ZAML[24]
WT1RMFPNAPYLHLA-A0201F2, F3PhageF2-28Z/F3-28ZLeukemia[26]
RMFPNAPYLHLA-A0201Clone 45PhageClone45-4-1BBZLeukemia[23]
HA-1HVLHHDLLEAHLA-A0201#131Phage#131-28ZLeukemia[19]
NY-ESO-1SLIMWITQCHLA-A0201T1PhageT1-28ZMelanoma[25]
AFPFMNKFIYETHLA-A0201ET1402L1PhageET1402L1-28ZLiver cancer[27]

Notes: published TCR-like antibody CAR-T targeting cancer antigens are summarized. MHC: major histocompatibility complex; CAR: chimeric antigen receptor.

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