Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis

Figure 2

The canonical pathway and activation mechanism of inflammasomes and outcomes in cancer. PAMP and DAMP signals are recognized by PRRs/TLRs, which then lead to activation of caspases. Active caspase-1 will promote the IL-β and IL-18 release or pyroptosis initiation, through GSDMD cleavage and pore formation (image created in https://BioRender.com).