|
| Components of inflammasome pathway | Role | Cancer type | Experimental models |
|
| AIM2 | Enhances cell proliferation and tumor migration | Cutaneous squamous cell carcinoma (cSCC) | Surgically removed human SCC of the skin [63] |
| NLRP3 | Supports fast cancer cell migration in vitro and metastatic ability in vivo | Colorectal cancer | Human colon cancer cell line SW480, LoVo
Mouse colon cancer cell line MC38, CT26
Mouse bone marrow [65] |
| Actively implicated in proliferation (in vitro) and metastasis (in vivo) | Oral squamous cell carcinoma (OSCC) | OSCC cell line
Normal human oral epithelial cells
Mouse xenograft model [67] |
| Supports tissue damage like with tumor-promoting inflammation in cancer-associated fibroblasts | Breast carcinogenesis | Mouse stains: FVB/N-Tg MMTV-PyMT 634Mul/J transgenic mice, Nlrp3−/− mice, nontransgenic FVB/n mice, Balb/c mice, and C57BL/6J mice
Cell lines: Met-1 (the mouse malignant neoplasms of the mouse mammary gland), 4T1(mimic stage IV human breast cancer) [68] |
| Mediates inflammation during cancer development via histone regulation | Renal cancer | Human kidney carcinoma cell line (A498)
Human clear cell renal cell carcinoma confirmed histological sections [69] |
| ASC | Tumor-promoting effects via the NF-κB signaling pathway | Gastric cancer | gp130F/F: Asc−/−, gp130F/F: Il1r−/−, and gp130F/F: Il18−/− stomach mouse tissue and bone marrow cells [66] |
| Protumorigenic functions | Gastric cancer | Human gastric biopsies [66] |
| NLRP1 | Promotes tumor growth and suppresses apoptotic pathways | Melanoma | THP-1 (human leukemia monocytic cells) cells and 13 human melanoma cell lines [70] |
|
