Review Article

Diagnosis and Treatment of Rheumatic Adverse Events Related to Immune Checkpoint Inhibitors

Table 1

General terminology standard for adverse event (CTCAE) version 5.0.

LevelClinical description

1Mild: asymptomatic or mild; only clinical or diagnostic; no treatment required
2Moderate: requires minor, local, or noninvasive treatment; age equivalent instrumental ADL limitation
3Serious or medically significant but not immediately life-threatening
Causes hospitalization or prolongation of hospitalization; disability; self-care ADL limitation
4Life threatening; in need of urgent treatment
5Death-related AE