sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

Table 2

The results of the receiver operating characteristic (ROC) curve analysis and evaluation of the above-mentioned parameters of blood markers for AA.

Parameters	Cutoff values	AUROC	Sensitivity (SE)	Specificity (SP)	PPV	NPV	+LR	-LR
sB7H3 (ng/mL)	17.850	1	1.000	1.000	1.000	1.000	—	0.000
CRP (mg/L)	1.905	0.983	0.935	0.967	0.966	0.935	0.280	0.001
WBC (1000/μL)	12.495	0.895	0.826	0.878	0.874	0.832	0.068	0.002
Dbil (μmol/L)	2.45	0.874	0.891	0.778	0.804	0.875	0.040	0.001
FIB (g/L)	3.11	0.845	0.728	0.911	0.893	0.766	0.082	0.003
Tbil (μmol/L)	8.315	0.831	0.761	0.789	0.787	0.763	0.036	0.003
PDW (%)	12.05	0.776	0.674	0.800	0.775	0.706	0.034	0.004
Ibil (μmol/L)	6.875	0.772	0.522	0.900	0.842	0.648	0.052	0.005
MCV (fL)	80.5	0.724	0.761	0.589	0.654	0.707	0.019	0.004
RDW (%)	12.85	0.711	0.902	0.456	0.629	0.820	0.017	0.002

The ROC curve is drawn by SPSS, and Youden’s index is calculated by the corresponding coordinate value on the curve. The maximum value of Youden’s index is the ideal cutoff value. AUROC: area under the curve; PPV: positive predictive value; NPV: negative predictive value; +LR: positive likelihood ratios; -LR: negative likelihood ratios; CRP: C-reactive protein; WBC: white blood cell; Dbil: direct bilirubin; FIB: fibrinogen; Tbil: total bilirubin; PDW: platelet distribution width; MCV: mean corpuscular volume; PDW: platelet distribution width; Ibil: indirect bilirubin; MCV: mean corpuscular volume; RDW: red blood cell distribution width.