CpG-ODN Induces a Dose-Dependent Enrichment of Immunological Niches in the Spleen and Lungs of Neonatal Chicks That Correlates with the Protective Immunity against <i>Escherichia coli</i>

<div>Histology of the spleen. Hematoxylin and eosin staining 72 hrs post <i>in ovo</i> injections revealed higher cellular infiltration in the spleen of birds treated with 25 <i>μ</i>g CpG-ODN compared to saline control. Higher cellular infiltration was seen with CpG-ODN treatment (b) compared to saline (a) in low power (4x). High power magnification (100x) (d) and the magnified inset (f) showed that these cells mainly comprised of a mononuclear (macrophages) cell population (black arrows) and lymphocytes (red arrows).</div>

Journal of Immunology Research

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Figure 4

Figure 4: CpG-ODN Induces a Dose-Dependent Enrichment of Immunological Niches in the Spleen and Lungs of Neonatal Chicks That Correlates with the Protective Immunity against <i>Escherichia coli</i> 

Figure 4 | CpG-ODN Induces a Dose-Dependent Enrichment of Immunological Niches in the Spleen and Lungs of Neonatal Chicks That Correlates with the Protective Immunity against Escherichia coli 