Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain: In Silico Analysis

Figure 2

Structural alignment of the SARS-CoV-2 RNA binding domain of nucleocapsid phosphoprotein. Helices are represented in squiggles, while beta strands with arrows and turns with TT letters. Solvent accessibility is rendered by a first bar below the sequence (blue is accessible, cyan is intermediate, and white is buried) and hydropathy by a second bar below (pink is hydrophobic, white is neutral, and cyan is hydrophilic). Bottom letters and symbols depict crystallographicity. Alignments in red represent conserved regions, yellow highlights the regions that tend towards monomorphism, while white is regions that are highly mutated. The dotted segments are the sequence deletions.