Integrated Bioinformatics Analysis Identifies ELAVL1 and APP as Candidate Crucial Genes for Crohn’s Disease

Figure 1

Screening DEGs by integrated bioinformatics analysis. The gene expression and connectivity of GSE86434 and GSE94648 (a), GSE86434 and GSE119600 (b), and GSE94648 and GSE119600 (c). After moving batch effects with parametric empirical Bayes frameworks provided by the ComBat function in R package sva, the gene expression and connectivity of GSE86434 and GSE94648 (d), GSE86434 and GSE119600 (e), and GSE94648 and GSE119600 (f). (g) PCA plot for sample clustering of all datasets without batch effect adjustment (A) and with batch effect adjustment (B). (h) Venn diagram of integrative analysis DEGs (Integrated-DE) and DEGs from each individual dataset (Individual-DE).

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