The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4⁺ T Cell Subsets

Figure 2

mTORC1 and mTORC2 differently regulate the differentiation of CD4⁺ Th cell subsets. Th1 and Th17 cell differentiation are positively regulated by mTORC1. Th2 cell differentiation is positively regulated by mTORC2. Both mTORC1 and mTORC2 positively regulate Th9, Tfh, and CD8 cell differentiation. Both mTORC1 and mTORC2 negatively regulate Treg cell differentiation.