The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4⁺ T Cell Subsets

Figure 5

The regulation of mTOR on Th17 cell differentiation. Th17 cell differentiation is regulated mainly by mTORC1. mTORC1 positively regulates the Rorc expression and Th17 cell differentiation through the following pathways: (1) inhibiting the expression of SOCS3, which could inhibit the activation of STAT4; (2) regulating the expression of Rorc through the SGK1-Gfi1 signaling pathway; (3) promoting the nuclear translocation of RORγ through S6K2; and (4) activating the HIF1α-dependent glycolytic pathway.