miR-21 and Pellino-1 Expression Profiling in Autoimmune Premature Ovarian Insufficiency

Figure 4

Ovary structure and immune parameters of patients. (a) Antral follicles are observed in the ovary of a normal-cycling woman while no follicle images are seen in an autoimmune POI patient under ultrasonography. (b) Antibodies and immunity factors were considered immune parameters. Two or more positive immune parameters were found in 85.5% of autoimmune POI patients. (c) Ovarian volume was measured with ultrasound examination and decreased in the autoimmune POI group. (d) Peli1 mRNA was measured by qRT-PCR in PBMCs isolated from the peripheral blood of each participant of both groups. The relative expression of Peli1 mRNA in autoimmune POI patients is dramatically lower than normal-cycling women.

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