Increased Circulating Th1 and Tfh1 Cell Numbers Are Associated with Disease Activity in Glucocorticoid-Treated Patients with IgG4-Related Disease

Figure 2

Tfh cell subset analysis in active IgG4-RD patients, remission IgG4-RD patients, and healthy controls. (a) Representative dot plots for FCM analysis. Tfh1, Tfh2, and Tfh17 were defined as CD4⁺CXCR5⁺Foxp3^-CXCR3⁺CCR6^- cells, CD4⁺CXCR5⁺Foxp3^-CXCR3^- CCR6^- cells, and CD4⁺CXCR5⁺Foxp3^-CXCR3^-CCR6⁺ cells, respectively. (b) The absolute numbers (per μL) and frequencies of circulating Tfh subsets in active IgG4-RD patients (), remission IgG4-RD patients (), and HC (). The error bars represented the median and interquartile range. The Mann–Whitney test was used to compare the subset levels. ns, (not significant); ; ; ; .

(a)

(b)