Increased Circulating Th1 and Tfh1 Cell Numbers Are Associated with Disease Activity in Glucocorticoid-Treated Patients with IgG4-Related Disease

Figure 5

ROC analysis of the values of Tfh and Th subsets in the diagnosis of active IgG4-RD. Th (up) and Tfh (down) subset levels in 39 cases of IgG4-RD patients were analyzed, including 29 active and 10 remission IgG4-RD patients. The receiver operating characteristic (ROC) curves were performed to evaluate the efficacy of Th or Tfh subsets to distinguish active IgG4-RD from remission IgG4-RD patients. The areas under the curve (AUC) were 0.8276 for Th1 cells, 0.7586 for Th2 plus naïve CD4 cells, and 0.6517 for Th17 cells, and AUC were 0.7310 for Tfh1 cells, 0.5862 for Tfh2 cells, and 0.6810 for Tfh17 cells.