SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity

Figure 2

CAC tumorigenesis is suppressed in Sirt5 KO mice. (a) Representative photos of colons and colon length of WT and Sirt5 KO mice on day 75. (b) Colon length of WT () and KO () mice. (c) Representative photos of colon tumors in WT and KO mice. (d) Numbers of colon tumors in WT () and KO () mice. (e) Tumor load of colon tumors in WT () and KO () mice. (f) Size of colon tumors in WT () and KO () mice. (g) Size distribution of colon tumors with indicated diameters in WT and KO mice. (h) Colon mucosal histology of WT and KO mice was examined by H&E staining of paraffin-embedded sections. Single arrow shows infiltration of inflammatory cells. Arrowhead shows crypt hyperplasia and necrotic lesions. Scale bars, 100 μm. (i) Histological scores of WT () and KO () mice according to H&E staining results. (j) Levels of related cytokines in colon tissues of WT () and KO () mice. The data are shown as the . ; ; n.s.: not significant; two-tailed unpaired -test.

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