miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT

Figure 1

miR-24-3p was negatively associated with KLF8 mRNA expression and was closely related to EMT markers (Snail and E-cadherin mRNA). (a) miR-24-3p expression in lung adenocarcinoma was less than that in normal tissues. (b) KLF8 mRNA expression in lung adenocarcinoma was higher than that in normal tissues. (c) Regression analysis comparing miR-24-3p and KLF8 mRNA expressions in lung adenocarcinoma tissues and the corresponding normal tissues. (d) Snail mRNA expression in lung adenocarcinoma tissues was higher than that in normal tissues. (e) E-cadherin mRNA expression in lung adenocarcinoma was less than that in normal tissues. (f) Regression analysis comparing miR-24-3p and E-cadherin mRNA expressions in lung adenocarcinoma tissues and the corresponding normal tissues. (g, h) Kaplan-Meier estimates of the cumulative survival rate based on the Kaplan-Meier plotter database. The higher KLF8 and Snail mRNA expression were closely related to poor prognosis in lung adenocarcinoma.

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