Blocking Interleukin-33 Alleviates the Joint Inflammation and Inhibits the Development of Collagen-Induced Arthritis in Mice

Figure 4

Effect of anti-IL-33 on serum proinflammatory cytokine production. Mice treated with anti-IL-33 or control IgG were killed on day 43, and the serum was collected from eight mice in each group. Levels of IFN-γ (a), IL-6 (b), IL-12 (c), TNF-α (d), IL-33 (e), and sST2 (f) were determined by ELISA. Data are (); , vs. the control IgG group by two-tailed unpaired Student’s -test.

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