Journal of Immunology Research / 2020 / Article / Fig 2

Research Article

ChIP-seq Profiling Identifies Histone Deacetylase 2 Targeting Genes Involved in Immune and Inflammatory Regulation Induced by Calcitonin Gene-Related Peptide in Microglial Cells

Figure 2

Effect of CGRP on the enriched region (peak) distribution of the ChIP-seq reads of HDAC2 in microglia treated with CGRP compared with the control. (a) Genome-wide distribution of enrichments relative to annotated genes. (b) The peak distribution of ChIP-seq reads of HDAC2 in control and microglial cells treated with CGRP. (c) The distribution of HDAC2 peaks on promoters relative to gene transcription start sites (TSSs). Shown are HDAC2 peak frequencies relative to the distance from the nearest annotated TSS in microglial cells treated with CGRP.

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